We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathophysiology of Drug-Induced Hypomagnesaemia.
- Authors
Katopodis, Periklis; Karteris, Emmanouil; Katopodis, Konstantinos P.
- Abstract
Magnesium (Mg2+) is the second most abundant intracellular and fourth extracellular cation found in the body and is involved in a wide range of functions in the human cell and human physiology. Its role in most of the enzyme processes (ATP-ases)-stabilisation of nucleic acids (DNA, RNA), regulation of calcium and potassium ion channels, proliferation, glucose metabolism and apoptosis-make it one of the most important cations in the cell. Three pathogenetic mechanisms are mainly implicated in the development of hypomagnesaemia: reduced food intake, decreased intestinal absorption and increased renal excretion of Mg2+. This review presents the function of Mg2+, how it is handled in the kidney and the drugs that cause hypomagnesaemia. The frequency and the number of drugs like diuretics and proton-pump inhibitors (PPIs) that are used daily in medical practice are discussed in order to prevent and treat adverse effects by providing an insight into Mg2+ homeostasis.
- Subjects
MAGNESIUM; INTRACELLULAR calcium; CATION analysis; HUMAN cell membranes; HUMAN physiology
- Publication
Drug Safety, 2020, Vol 43, Issue 9, p867
- ISSN
0114-5916
- Publication type
journal article
- DOI
10.1007/s40264-020-00947-y