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- Title
Effect of intensive versus standard blood pressure control on depression and health-related quality of life in type 2 diabetes: the ACCORD trial.
- Authors
O'Connor PJ; Narayan KM; Anderson R; Feeney P; Fine L; Ali MK; Simmons DL; Hire DG; Sperl-Hillen JM; Katz LA; Margolis KL; Sullivan MD; O'Connor, Patrick J; Narayan, K M Venkat; Anderson, Roger; Feeney, Patricia; Fine, Larry; Ali, Mohammed K; Simmons, Debra L; Hire, Don G
- Abstract
<bold>Objective: </bold>We tested the hypothesis that intensive (systolic blood pressure [SBP] <120 mmHg) rather than standard (SBP 130-139 mmHg) blood pressure (BP) control improves health-related quality of life (HRQL) in those with type 2 diabetes.<bold>Research Design and Methods: </bold>Subjects were 1,028 ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial HRQL substudy participants who completed baseline and one or more 12-, 36-, or 48-month HRQL evaluations. Multivariable linear regression assessed impact of BP treatment assignment on change in HRQL.<bold>Results: </bold>Over 4.0 years of follow-up, no significant differences occurred in five of six HRQL measures. Those assigned to intensive (vs. standard) BP control had statistically significant worsening of the Medical Outcomes Study 36-item short-form health survey (SF36) physical component scores (-0.8 vs. -0.2; P = 0.02), but magnitude of change was not clinically significant. Findings persisted across all prespecified subgroups.<bold>Conclusions: </bold>Intensive BP control in the ACCORD trial did not have a clinically significant impact, either positive or negative, on depression or patient-reported HRQL.
- Publication
Diabetes Care, 2012, Vol 35, Issue 7, p1479
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc11-1868