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- Title
An epidermal growth factor receptor exon 19 mutation in a mucin-producing gastric cancer sample from a Chinese patient.
- Authors
Weipeng Lu; Mei Li; Hai Wang; Lina Liu; Shen Lu
- Abstract
Objective: To determine whether a subgroup of gastric cancer patients might benefit from epidermal growth factor receptor-tyrosine kinase inhibitors. Methods: A total of 103 gastric cancer sampleswere collected for this study. High-resolution melting and deoxyribonucleic acid sequencing were used to detect epidermal growth factor receptor mutations in exons 19 and 21. Results: Polymerase chain reaction-high-resolution melting was successfully performed on all 103 samples. Aberrant melting curves were found in only one sample. Sanger sequencing revealed a 15 bp deletion (c.2235_2249del; p.Glu746_Ala750del) in epidermal growth factor receptor exon 19. The sample was from a male patient, and the pathological diagnosis was a mucin-producing gastric cancer with lymph node metastasis. To date, this is the first report on epidermal growth factor receptor exon 19 mutation in gastric cancer. Conclusions: An epidermal growth factor receptor mutation in exon 19 was identified in mucinproducing gastric cancer sample from a male patient. This mutation indicates that the small subgroup of patients with mucin-producing gastric cancer might benefit from epidermal growth factor receptor-tyrosine kinase inhibitors.
- Publication
Japanese Journal of Clinical Oncology, 2016, Vol 46, Issue 6, p502
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyw033