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- Title
Splenic Irradiation for Prolymphocyte Leukemia: Is it Preferable as an Initial Treatment or Not?
- Authors
Yamamoto, Katsuya; Hamaguchi, Hiroyuki; Nagata, Kaoru; Shibuya, Hitoshi; Takeuchi, Hitoshi
- Abstract
We describe a case of B-cell prolymphocyte leukemia (PLL) successfully treated with splenic irradiation (SI). A 69-year-old woman was admitted to our hospital because of massive splenomegaly and leukocytosis. Peripheral blood showed hemoglobin (Hb) 7.4 g/dl, platelets 48 × 109/l and white blood cells (WBC) 50.3 × 109/l with 90% prolymphocytes. Bone marrow was hypercellular with 60% prolymphocytes. Surface marker analysis revealed that prolymphocytes were positive for CD20, CD22, FMC7, HLA-DR and surface immunoglobulin (µ, δ and λ), but negative for CD5 and mouse erythrocyte rosette. A diagnosis of B-cell PLL was made. SI (1.5 Gy × 4/week, total dose 19.5 Gy) was chosen for the treatment and a remarkable response was achieved immediately after the first irradiation. Finally, a single course of SI induced complete remission without any significant side effect. One year after the SI, she showed no splenomegaly and almost normal peripheral blood cell count (Hb 11.2 g/dl, platelets 100 × 109/l, WBC 3.6 × 109/l with 71% neutrophils and no prolymphocyte). She has been well for more than 24 months. This case showed that SI may remain valuable for an initial course of PLL treatment.
- Publication
Japanese Journal of Clinical Oncology, 1998, Vol 28, Issue 4, p267
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/28.4.267