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- Title
Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children.
- Authors
Rahbar, Mohammad H.; Samms-Vaughan, Maureen; Saroukhani, Sepideh; Lee, MinJae; Zhang, Jing; Bressler, Jan; Hessabi, Manouchehr; Shakespeare-Pellington, Sydonnie; Grove, Megan L.; Loveland, Katherine A.
- Abstract
Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2–8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.
- Subjects
JAMAICA; GLUTATHIONE; GENETICS; GENETIC polymorphisms; MANGANESE; SOCIOECONOMIC factors; AUTISM; TRANSFERASES; LOGISTIC regression analysis; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2021, Vol 51, Issue 6, p1953
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-020-04677-z