We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression of the Broad Autism Phenotype in Simplex Autism Families from the Simons Simplex Collection.
- Authors
Davidson, Julie; Goin-Kochel, Robin; Green-Snyder, Lee; Hundley, Rachel; Warren, Zachary; Peters, Sarika
- Abstract
The broad autism phenotype (BAP) refers to the phenotypic expression of an underlying genetic liability to autism, manifest in non-autistic relatives. This study examined the relationship among the Broad Autism Phenotype Questionnaire (BAPQ), Social Responsiveness Scale: Adult Research Version (SRS:ARV), and Family History Interview (FHI) in a large, multi-site study of 1,650 simplex families (Simons Simplex Collection). Correlations between the BAPQ and SRS:ARV Total scores were moderate, and correlations between FHI ratings and SRS:ARV and BAPQ were significant but weak. Overall, the results suggested that BAP traits occur at low rates in simplex families, and rates vary significantly depending upon the measure utilized. Implications include the need for multiple informants, and the assessment of distinct BAP traits in large-scale genetic studies of individuals with ASD.
- Subjects
GENETICS of autism; STATISTICAL correlation; GENE expression; GENETIC research; INTERVIEWING; RESEARCH methodology; MEDICAL cooperation; PARENTS; QUESTIONNAIRES; RESEARCH; RESEARCH funding; SCALE analysis (Psychology); SEX distribution; T-test (Statistics); PHENOTYPES; SECONDARY analysis; MULTITRAIT multimethod techniques; RESEARCH methodology evaluation
- Publication
Journal of Autism & Developmental Disorders, 2014, Vol 44, Issue 10, p2392
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-012-1492-1