We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
β-Blockers as Initial Therapy for Hypertension.
- Authors
Wiysonge, Charles S.; Opie, Lionel H.
- Abstract
CLINICAL QUESTION Are β-blockers associated with lower rates of all-cause mortality and cardiovascular events when used as initial treatment in individuals with hypertension compared with placebo, no treatment, or other drugs? BOTTOM LINE Initial therapy of hypertension with β-blockers is not associated with reduced all-cause mortality but is associated with modest reductions in cardiovascular events compared with placebo or no treatment. Calcium channel blockers and renin-angiotensin system inhibitors are associated with greater reductions in cardiovascular event rates than β-blockers. This evidence derives from trials of traditional p-blockers (eg, atenolol and propranolol), because there are currently no mortality and cardiovascular event data on the new vasodilating β-blockers (eg, carvedilol and nebivolol).
- Subjects
ADRENERGIC beta blockers; THERAPEUTICS; HYPERTENSION; MORTALITY; PLACEBOS; CALCIUM antagonists; RENIN-angiotensin system
- Publication
JAMA: Journal of the American Medical Association, 2013, Vol 310, Issue 17, p1851
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2013.277510