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- Title
Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants.
- Authors
Jianming Tan; Weizhen Wu; Xiumin Xu; Lianming Liao; Feng Zheng; Messinger, Shari; Xinhui Sun; Jin Chen; Shunliang Yang; Jinquan Cai; Xia Gao; Pileggi, Antonello; Ricordi, Camillo
- Abstract
The article discusses a randomized clinical study of the effect of autologous mesenchymal stem cells (MSC) infusion as a replacement of anti-interleukin (IL)-2 receptor antibody induction for patients with end-stage renal disease who undergo living-related donor kidney transplants. The researchers recruited 150 patients from February 2008 to May 2009, of whom 53 received standard-dose and 52 received low-dose of calcineurin inhibitors. They found that the use of autologous MSC resulted in lower incidence of acute rejection and reduced risk of opportunistic infection in patients undergoing renal patient as compared with those receiving anti-IL-2 antibody induction therapy.
- Subjects
MESENCHYMAL stem cells; IMMUNOGLOBULINS; INTERLEUKIN-2; KIDNEY transplantation; CALCINEURIN; ORGAN donors
- Publication
JAMA: Journal of the American Medical Association, 2012, Vol 307, Issue 11, p1169
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2012.316