We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100<sup>®</sup> in patients undergoing neuroendovascular procedures.
- Authors
Rolling, Christina C.; Tomada, Julia; Frölich, Andreas M.; Holst, Brigitte; Holstein, Katharina; Voigtländer, Minna; Janjetovic, Snjezana; Haddad, Munif; Renné, Thomas; Fiehler, Jens; Bokemeyer, Carsten; Rolling, Thierry; Langer, Florian
- Abstract
Objectives: Dual platelet inhibition is commonly used for prevention of cardiovascular events in patients undergoing neuroendovascular procedures. Non-responsiveness to platelet inhibitors may be associated with adverse outcomes. The aim of this study was to evaluate the reliability of the platelet function analyzer PFA-100® in comparison to light transmittance aggregometry (LTA) for monitoring clopidogrel and acetylsalicylic acid (ASA) non-responsiveness in a cohort of patients treated for intracranial aneurysm or cranial artery stenosis. Methods: Non-responsiveness to clopidogrel and ASA was assessed by LTA using adenosine diphosphate (ADP) and arachidonic acid and by PFA-100® with the ADP/prostaglandin E1 (PGE1) and collagen/epinephrine cartridges, respectively. Results: A total of 203 patients (145 females; median age, 57 years) were analyzed. Agreement between the two tests was poor for clopidogrel non-responsiveness (ƙ=0.19) and not better than chance for ASA non-responsiveness (ƙ=0.01). Clopidogrel non-responsiveness by LTA and PFA-100® was associated with higher von Willebrand factor antigen and activity levels. ADP-induced platelet disaggregation was lower in patients with clopidogrel non-responsiveness as assessed by PFA-100®. Clopidogrel non-responsiveness by LTA was associated with a higher prevalence of diabetes and a higher body mass index (BMI). Adverse outcomes (death, thromboembolism, or in-stent thrombosis) occurred in 13% (n=26) of all patients independently of ASA and clopidogrel non-responsiveness as assessed by both devices. Conclusions: Our results show that LTA and PFA-100® are not interchangeable in the assessment of ASA and clopidogrel non-responsiveness in patients undergoing neuroendovascular interventions.
- Subjects
PRASUGREL; ASPIRIN; CLOPIDOGREL; PLATELET aggregation inhibitors; ARTERIAL stenosis; ADENOSINE diphosphate; VON Willebrand factor
- Publication
Clinical Chemistry & Laboratory Medicine, 2021, Vol 59, Issue 1, p383
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2020-0737