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- Title
FİBROMİYALJİLİ HASTALARDA KİŞİLİK ÖZELLİKLERİNE GÖRE PREGABALİN VE DULOKSETİN TEDAVİLERİNİN ETKİNLİĞİNİN KARŞILAŞTIRILMASI.
- Authors
ÇELEBİ, Esra; ATAOĞLU, Safinaz; ATAOĞLU, B. Bahar; ANKARALI, Handan; ÖZŞAHİN, Mustafa; PASİN, Özge
- Abstract
This study was to compare the effects of duloxetine and pregabalin on fibromyalgia(FMS) patients with different personalities. A total of 102 female with FMS who applied to outpatient clinics of the Department of Physical Medicine and Rehabilitation in Duzce University Medical School between October (2013)- December (2014),were grouped according to their personality characteristics. Each personality group was also randomly divided in two groups. One group received 60 mg/day duloxetine and the other group received 300 mg/day pregabalin for 12 weeks.The pain intensity of the patients was evaluated with VAS,their sleep quality was evaluated with VAS–sleep score,depression was evaluated with Beck Depression Scale(BDS), quality of life was evaluated with SF-36, and functioning was evaluated with Fibromyalgia Impact Questionnaire(FIQ) before and after treatment. Thirty of the neurotic group received duloxetine, 31 received pregabalin while 20 of the extroverts received duloxetine and 21 received pregabalin.Significant improvements were obtained in the neurotic-duloxetine and extroverted-pregabalin groups in terms of BDS and general health perceptions dimension of SF-36. Significant improvements were observed in all groups in terms of VAS,VAS-Sleep and sensitive points.The increase after treatment in physical functioning,physical role functioning, vitality,mental health and bodily pain in SF-36 was significant in all groups.The increase in emotional role functioning was significantly higher in only neurotic-duloxetine and neurotic–pregabalin groups.Whereas the effects of treatments were not found statistically significant on vitality in all groups.The decrease in FIQ scores was significant in extroverted–duloxetine and extroverted–pregabalin groups. Treatment should be initiated with pregabalin in extroverts, and duloxetine in neurotics.
- Publication
Duzce Medical Journal, 2016, Vol 18, Issue 2, p47
- ISSN
1307-671X
- Publication type
Article