We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lymphomas of the Breast: A Clinicopathological Study Over 12 Years.
- Authors
Sur, Monalisa; Dhamanaskar, Prashant K.; Akhtar-Danesh, Noori; Elavathil, Leela
- Abstract
Non-Hodgkin's lymphomas of the breast are rare and represent 0.04-0.50% of malignant lesions of the breast. Most cases are of a B-cell phenotype and are more commonly identified on the right side. This series summarizes our experience at a regional cancer centre over the past 12 years with all cases of lymphoma of the breast based on the World Health Organization (WHO) 2008 classification. We analyzed the clinicopathological and immunophenotypical characteristics of 40 breast lymphomas and the relative frequency of primary versus secondary lymphomas. Statistical analysis of survival data based on disease progression, frequency of primary versus secondary origin, and subtype in the WHO classification were also assessed. In our series of 40 breast lymphomas, primary lymphoma was more common (63%) than secondary lymphoma (37%). Involvement of the right breast (63%) was significantly more frequent than that of the left breast (35%). Only one case of T-acute lymphoblastic lymphoma (T-ALL) showed bilateral breast involvement. Overall, B-cell lymphomas constituted the majority of lymphomas (88%). Diffuse large B-cell lymphoma (DLBCL) was the most common subtype (40%), followed by MALT lymphoma and follicular lymphoma (20% each). B-chronic lymphocytic lymphoma/leukemia constituted only 5% of the lesions. DLBCL was the most common subtype of both primary and secondary lymphomas. Rarer subtypes (20%) included nasal natural killer/T-cell lymphoma, T-ALL, B-acute lymphoblastic lymphoma, peripheral T-cell lymphoma, and anaplastic large-cell lymphoma. The overall 5-year and 10-year survival rates were 78% and 67%, respectively. In our series, patients with secondary lymphoma involving the breast and those with high-grade histology fared worse than those with primary involvement and low-grade histology. Thus, the histological subtype, type of involvement (primary versus secondary), and stage of the disease affected the survival of these patients. All these factors should be taken into consideration in the management of breast lymphomas.
- Subjects
BREAST diseases; LYMPHOMAS; WORLD Health Organization; B cells; LEUKEMIA
- Publication
Canadian Journal of Pathology, 2009, Vol 1, Issue 4, p12
- ISSN
1918-915X
- Publication type
Article