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- Title
Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs.
- Authors
Cha, Jae‐Kook; Lee, Jung‐Seok; Kim, Min‐Soo; Choi, Seong‐Ho; Cho, Kyoo‐Sung; Jung, Ui‐Won
- Abstract
Aim The objective of this study was to determine the efficacy of bone morphogenetic protein 2 ( BMP-2) in a bovine hydroxyapatite/collagen ( BHC) carrier to augment bone formation in a canine nasal sinus model. Methods Eight mongrel dogs, approximately 12 months old and 30 kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E. coli-derived BMP-2 at 0.1 mg/ml was implanted in four animals, and BHC loaded with E. coli-derived BMP-2 at 0.5 and 1.5 mg/ml was implanted in four animals. The animals were euthanized at 20 weeks when block sections were obtained for micro-computed tomography and histometric analyses. Results Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP-2 groups compared with control. Conclusion BMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.
- Subjects
KOREA; BONE morphogenetic proteins; ACADEMIC medical centers; BONE remodeling; ANIMAL experimentation; DOGS; PARANASAL sinuses; RESEARCH funding; STATISTICS; TOMOGRAPHY; U-statistics; DATA analysis; EQUIPMENT &; supplies; THERAPEUTICS
- Publication
Journal of Clinical Periodontology, 2014, Vol 41, Issue 1, p86
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12174