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- Title
Late-life depression, subjective cognitive decline, and their additive risk in incidence of dementia: A nationwide longitudinal study.
- Authors
Wang, Sheng-Min; Han, Kyung-do; Kim, Nak-Young; Um, Yoo Hyun; Kang, Dong-Woo; Na, Hae-Ran; Lee, Chang-Uk; Lim, Hyun Kook
- Abstract
Objective: Late-life depression and subjective cognitive decline (SCD) are significant risk factors for dementia. However, studies with a large sample size are needed to clarify their independent and combined risks for subsequent dementia. Methods: This nationwide population-based cohort study included all individuals aged 66 years who participated in the National Screening Program between 2009 and 2013 (N = 939,099). Subjects were followed from the day they underwent screening to the diagnosis of dementia, death, or the last follow-up day (December 31, 2017). Results: Depressive symptom presentation, recent depressive disorder, and SCD independently increased dementia incidence with adjusted hazard ratio (aHR) of 1.286 (95% CI:1.255–1.318), 1.697 (95% CI:1.621–1.776), and 1.748 (95% CI: 689–1.808) respectively. Subjects having both SCD and depression had a higher risk (aHR = 2.466, 95% CI:2.383–2.551) of dementia than having depression (aHR = 1.402, 95% CI:1.364–1.441) or SCD (aHR = 1.748, 95% CI:1.689–1.808) alone. Conclusions: Depressive symptoms, depressive disorder, and SCD are independent risk factors for dementia. Co-occurring depression and SCD have an additive effect on the risk of dementia; thus, early intervention and close follow up are necessary for patients with co-occurring SCD and depression.
- Subjects
DEMENTIA; AGE factors in cognition disorders; MENTAL depression; LONGITUDINAL method; DIAGNOSIS; SAMPLE size (Statistics)
- Publication
PLoS ONE, 2021, Vol 16, Issue 7, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0254639