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- Title
ATIVIDADE DA LACTATO DESIDROGENASE (LDH) SÉRICA EM CÃES SUBMETIDOS À OXIGENAÇÃO EXTRACORPÓREA POR MEMBRANA (ECMO) POR UM PERÍODO DE TRÊS HORAS.
- Authors
Ferreira, Felipp Silveira; Silveira, Lara Lages; Costa, Alessandra Castello; Vale, Daniela Fantini; Carvalho, Claudio Baptista; Machado, Josias Alves; Abreu Oliveira, André Lacerda De
- Abstract
The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs
- Subjects
EXTRACORPOREAL membrane oxygenation; LACTATE dehydrogenase; LABORATORY dogs; BLOOD proteins; ARTIFICIAL respiration; CARDIOPULMONARY system; BLOOD circulation disorders
- Publication
Ciência Animal Brasileira, 2011, Vol 12, Issue 3, p554
- ISSN
1518-2797
- Publication type
Article
- DOI
10.5216/cab.v12i3.10148