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- Title
Multiplex Assessment of Serum Chemokines CCL2, CCL5, CXCL1, CXCL10, and CXCL13 Following Traumatic Brain Injury.
- Authors
Chen, Yuwen; Wang, Ying; Xu, Jian; Hou, Tingting; Zhu, Jing; Jiang, Yingzi; Sun, Liying; Huang, Chunling; Sun, Lulu; Liu, Su
- Abstract
Chemokines may promote neuroinflammation following traumatic brain injury (TBI), thereby exacerbating secondary injury. This study was designed to investigate the contributions of chemokines (CCL2, CCL5, CXCL1, CXCL10, and CXCL13) to TBI severity and clinical outcome. Peripheral blood was drawn from 92 TBI patients on admission, and 40 controls were recruited. Serum concentrations of CCL2, CCL5, CXCL1, CXCL10, and CXCL13 on admission were measured by ELISA. Preoperative clinical severity was evaluated using the Glasgow Coma Scale (GCS), and clinical outcome at 90 days post-TBI was evaluated using the Glasgow Outcome Scale (GOS). The associations were evaluated by calculating Spearman's correlation coefficients. A binary logistic regression model was used to identify clinicodemographic factors influencing outcome, and ROC curves were constructed. Serum concentrations of CCL2, CCL5, CXCL1, CXCL10, and CXCL13 were elevated significantly after TBI and negatively correlated with GCS and GOS scores except CCL5. CCL2 may be considered as an independent predictor to predict severity and outcome. Moreover, combination of GCS score, CCL2, and CXCL10 can be a better assessment prognosis of moderate and severe TBI.
- Subjects
BRAIN injuries; CHEMOKINES; GLASGOW Coma Scale; HOSPITAL admission &; discharge; RECEIVER operating characteristic curves
- Publication
Inflammation, 2023, Vol 46, Issue 1, p244
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-022-01729-7