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- Title
Synthesis of Diverse Seleno‐Glycolipids via the Transacetalization of Selenoacetals.
- Authors
Fukuo, Hayata; Suzuki, Tatsuya; Shimabukuro, Junpei; Komura, Naoko; Tanaka, Hide‐Nori; Imamura, Akihiro; Ishida, Hideharu; Ando, Hiromune
- Abstract
Seleno‐glycolipids, in which glycosidic oxygens are replaced with selenium atoms, are attractive detergents for X‐ray structural studies of membrane proteins. However, the development of seleno‐glycolipids has been hampered by difficulties associated with their chemical syntheses. In this study, we report a facile synthesis of novel seleno‐glycolipids with various glycan and lipid moieties, which proceeds via transacetalization of selenoacetals and glycosyl imidates. This work not only provides a route to monoseleno‐glycolipids, but also demonstrates the first synthesis of diseleno‐glycolipids.
- Subjects
GLYCOLIPIDS; MEMBRANE proteins; CHEMICAL synthesis; MOIETIES (Chemistry); SELENIUM; X-rays
- Publication
European Journal of Organic Chemistry, 2021, Vol 2021, Issue 40, p5455
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202100847