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- Title
A Convenient Synthesis of 1,2‐Disubstituted‐cis‐3,4‐Dihydroxypyrrolidines via an Ugi‐Four‐Component‐Reaction/Cycloisomerization/Dihydroxylation Protocol.
- Authors
Flores‐Constante, Gemma; Sánchez‐Chávez, Anahí C.; Polindara‐García, Luis A.
- Abstract
Dihydroxypyrrolidines constitute an important group of biologically active molecules that are found in nature. In this paper, we report the development of a selective method for the synthesis of 1,2‐disubstituted‐cis‐3,4‐dihydroxypyrrolidines from Ugi four‐component‐reaction/propargylamine adducts through a 5‐endo‐dig cycloisomerization and subsequent cis‐dihydroxylation process.
- Subjects
PYRROLIDINE synthesis; HYDROXYLATION; CYCLOISOMERIZATION; BIOACTIVE compounds; PROPARGYLAMINES
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 33, p4586
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201800756