We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Control of Invasive Salmonella Disease in Africa: Is There a Role for Human Challenge Models?
- Authors
Gibani, Malick M.; Jin, Celina; Darton, Thomas C.; Pollard, Andrew J.
- Abstract
Invasive Salmonella disease in Africa is a major public health concern. With evidence of the transcontinental spread of the Salmonella Typhi H58 haplotype, improved estimates of the burden of infection and understanding of the complex interplay of factors affecting disease transmission are needed to assist with efforts aimed at disease control. In addition to Salmonella Typhi, invasive nontyphoidal Salmonella are increasingly recognized as an important cause of febrile illness and mortality in sub-Saharan Africa. Human experimental oral challenge studies with Salmonella can be used as a model to offer unique insights into host–pathogen interactions as well as a platform to efficiently test new diagnostic and vaccine candidates. In this article, we review the background and use of human challenge studies to date and discuss how findings from these studies may lead to progress in the control of invasive Salmonella disease in Africa.
- Subjects
SALMONELLA diseases; PUBLIC health; INFECTIOUS disease transmission; PATHOGENIC microorganisms; SALMONELLA typhi
- Publication
Clinical Infectious Diseases, 2015, Vol 61, pS266
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/civ673