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- Title
Stanniocalcin-1 mRNA expression in soft-tissue tumors.
- Authors
Tetsuro Yamagishi; Hiroyuki Kawashima; Akira Ogose; Takashi Ariizumi; Naoki Oike; Taro Sasaki; Hiroshi Hatano; Naoto Endo
- Abstract
Stanniocalcin-1 (STC1) is a glycoprotein that was originally identified as a calcium-regulating hormone in bony fish, and that has been shown to also critically mediate cell growth, proliferation and differentiation, etc. in humans. Increased STC1 expression levels have been previously detected in different human cancer samples, such as those isolated from lung, breast, ovary, colon, pancreas, and liver tumors; thus, the present study evaluated STC1 expression in various soft-tissue tumors. STC1 mRNA isolated from 16 cell lines and 186 clinical soft-tissue tumor specimens were analyzed via quantitative real-time PCR, and the calculated expression levels were normalized to those exhibited by STC1-expressing MDA-MB-231 cells. The results of these analyses did not reveal any specific histological tumor types that displayed significantly increased STC1 expression; however, they did not indicate that STC1 expression was significantly higher in malignant compared to benign soft-tissue tumors. Furthermore, in adipocytic tumors, STC1 expression in dedifferentiated liposarcomas was found to be highest and lowest in lipoma tissues, respectively, suggesting that adipocytic tumors may express increasely high levels of STC1 mRNA as they become histologically more advanced. STC1 expression correlates with the malignancy grade in soft-tissue tumors.
- Subjects
MESSENGER RNA; GLYCOPROTEINS; SOFT tissue tumors; CELL growth; CALCIUM regulating hormones; CANCER cell proliferation; CELL proliferation
- Publication
Nagoya Journal of Medical Science, 2020, Vol 82, Issue 1, p85
- ISSN
0027-7622
- Publication type
Article
- DOI
10.18999/nagjms.82.1.85