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- Title
Small-Animal Imaging Using Clinical Positron Emission Tomography/Computed Tomography and Super-Resolution.
- Authors
DiFilippo, Frank P.; Patel, Sagar; Asosingh, Kewal; Erzurum, Serpil C.
- Abstract
Considering the high cost of dedicated small-animal positron emission tomography/computed tomography (PET/CT), an acceptable alternative in many situations might be clinical PET/CT. However, spatial resolution and image quality are of concern. The utility of clinical PET/CT for small-animal research and image quality improvements from super-resolution (spatial subsampling) were investigated. National Electrical Manufacturers Association (NEMA) NU 4 phantom and mouse data were acquired with a clinical PET/CT scanner, as both conventional static and stepped scans. Static scans were reconstructed with and without point spread function (PSF) modeling. Stepped images were postprocessed with iterative deconvolution to produce super-resolution images. Image quality was markedly improved using the super-resolution technique, avoiding certain artifacts produced by PSF modeling. The 2 mm rod of the NU 4 phantom was visualized with high contrast, and the major structures of the mouse were well resolved. Although not a perfect substitute for a state-of-the-art small-animal PET/CT scanner, a clinical PET/CT scanner with super-resolution produces acceptable small-animal image quality for many preclinical research studies.
- Subjects
POSITRON emission tomography; NATIONAL Electrical Manufacturers Association; TOMOGRAPHY; COST; MEDICAL artifacts; LABORATORY mice; IMAGE quality in imaging systems
- Publication
Molecular Imaging, 2012, Vol 11, Issue 3, p210
- ISSN
1535-3508
- Publication type
Article
- DOI
10.2310/7290.2011.00041