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- Title
Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design.
- Authors
Yun Ju Jun; Jinhee Lee; Sehee Hwang; Jung Hyun Kwak; Hyeon Yeong Ahn; Youn Kyung Bak; Jihoon Koh; Jong Ho Lee; Jun, Yun Ju; Lee, Jinhee; Hwang, Sehee; Kwak, Jung Hyun; Ahn, Hyeon Yeong; Bak, Youn Kyung; Koh, Jihoon; Lee, Jong Ho
- Abstract
<bold>Background: </bold>Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w).<bold>Methods: </bold>The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose:xylose = 10:1), 3.33 g (Test 2, sucrose:xylose = 15:1), or 2.5 g (Test 3, sucrose:xylose = 20:1) of D-xylose separated by a one-week interval.<bold>Results: </bold>Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group.<bold>Conclusion: </bold>Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes.<bold>Trial Registration: </bold>ClinicalTrials.gov identifier: NCT02654301 . Registered 12 January 2016.
- Subjects
SOUTH Korea; XYLOSE; GLYCEMIC control; CROSSOVER trials; PEOPLE with diabetes; DIETARY sucrose; HYPERGLYCEMIA; PATIENTS; HEALTH; BEVERAGES; BLOOD sugar; COMPARATIVE studies; HYPOGLYCEMIC agents; INGESTION; INSULIN; RESEARCH methodology; MEDICAL cooperation; MONOSACCHARIDES; ORAL drug administration; RESEARCH; TIME; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; BLIND experiment; DIAGNOSIS
- Publication
Trials, 2016, Vol 17, p1
- ISSN
1745-6215
- Publication type
journal article
- DOI
10.1186/s13063-016-1261-0