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- Title
Oxidant-antioxidant status in serum and saliva of oral squamous cell carcinoma patients.
- Authors
Kendole S. R. K.; Sahana S.
- Abstract
Background: Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the world. Reactive oxygen species (ROS) are postulated to be involved in carcinogenesis. The antioxidant defence system of our body limits cell injury induced by ROS. Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species and antioxidant capacity. This stress may cause mutagenesis and changes in gene expression that initiate or promote carcinogenesis. Aims and Objectives: The present study was conducted to assess oxidative stress and antioxidant capacity in patients with OSCC using serum and salivary samples and to compare these biomarkers in a group of healthy subjects. Materials and Methods: Twenty-five OSCC patients and 25 normal individuals were enrolled in the study. Unstimulated whole saliva and serum from OSCC patients and normal controls were analyzed for malondialdehyde (MDA) by photoelectric colorimetric method as indicator of oxidative stress and uric acid (UA) by biochemical analyzer as indicator of antioxidant defence. Results: In OSCC patients, UA was significantly lowerthan that in healthy subjects in their serum samples. Salivary MDAlevels were significantly higher in OSCC group compared with healthy subjects. A significant inverse correlation was found between salivary MDA and UA values in the OSCC patients. Conclusion: Increased levels of MDA indicate an increase in the oxidative stress in OSCC patients associated with a deficient antioxidant defence mechanism. Future studies regarding assessment of oxidant-antioxidant status in OSCC patients in view of selecting appropriate mode of therapy is to be carried out.
- Subjects
MALONDIALDEHYDE; SQUAMOUS cell carcinoma; REACTIVE oxygen species
- Publication
Journal of Oral & Maxillofacial Pathology (0973029X), 2014, Vol 18, pS12
- ISSN
0973-029X
- Publication type
Abstract