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- Title
SQ sublingual immunotherapy tablets for children with allergic rhinitis: A review of phase three trials.
- Authors
Csonka, Péter; Hamelmann, Eckard; Turkalj, Mirjana; Roberts, Graham; Mack, Douglas P.
- Abstract
Aim: To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double-blind, placebocontrolled trials in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma. Methods: PubMed searches were conducted and unpublished data were included if necessary. Results: Of the 93 publications, 12 were identified reporting 10 trials. One trial was excluded as paediatric-specific efficacy data were unavailable. The nine eligible trials evaluated grass, house dust mite, ragweed and tree SLIT tablets. Consistent reductions in allergic rhinitis or rhinoconjunctivitis symptoms and medication use were observed with SQ SLIT tablets versus placebo. In a five-year trial, sustained reduction of allergic rhinoconjunctivitis symptoms, asthma symptoms and medication use were observed with SQ grass SLIT tablet versus placebo. The number-needed-to-treat to prevent asthma symptoms and medication use in one additional child during follow-up was lowest in younger children. SQ SLIT tablets were generally well tolerated across trials. Conclusion: Evidence supports use of SQ SLIT tablets in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma. Long-term data demonstrate disease- modifying effects of SQ grass SLIT tablet and suggest the clinical relevance of initiating allergy immunotherapy earlier in the disease course.
- Subjects
ALLERGIC rhinitis; SUBLINGUAL immunotherapy; ALLERGIC conjunctivitis; ALLERGIC rhinoconjunctivitis; HOUSE dust mites
- Publication
Acta Paediatrica, 2024, Vol 113, Issue 6, p1209
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/apa.17221