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- Title
Probiotics promoted head growth in extremely low birthweight infants in a double-blind placebo-controlled trial.
- Authors
Wejryd, Erik; Marchini, Giovanna; Frimmel, Veronica; Jonsson, Baldvin; Abrahamsson, Thomas
- Abstract
<bold>Aim: </bold>This study evaluated if oral supplementation with the probiotic bacterium Lactobacillus reuteri DSM 17938 improved enteral feeding tolerance and growth rates in extremely low birthweight (ELBW) infants.<bold>Method: </bold>A randomised, double-blind, placebo-controlled trial comprising 134 ELBW (<1000 g) infants born before gestational week 28 + 0. Daily supplementation of L. reuteri (1.25 × 108 bacteria/day) or placebo started within 3 days and continued until gestational week 36 + 0. Primary outcome was feeding tolerance and secondary outcome growth rate calculated as z-score development.<bold>Results: </bold>Feeding tolerance was similar in the probiotic and placebo group. Time to full enteral feeds was 15 days in both groups. The z-score of the head circumference decreased in both groups from birth to day 28 of life, but it decreased less in the L. reuteri group compared to the placebo group: -1.2 SD (95% CI: -1.4 to -1.0) versus -1.7 SD (95% CI: -2.0 to -1.5; p = 0.001). Other growth parameters were similar in the study groups.<bold>Conclusion: </bold>Lactobacillus reuteri did not reduce time to reach full enteral feeds in ELBW infants. The L. reuteri supplemented infants, however, had a better growth rate of the head during the first month of life.
- Subjects
SWEDEN; HEAD growth; LOW birth weight; PROBIOTICS; LACTOBACILLUS; ENTEROCOLITIS; ENTERAL feeding; THERAPEUTIC use of probiotics; ACADEMIC medical centers; CEPHALOMETRY; CHILD development; COMPARATIVE studies; DIETARY supplements; GESTATIONAL age; HEAD; RESEARCH methodology; MEDICAL cooperation; NEONATAL intensive care; NONPARAMETRIC statistics; REFERENCE values; RESEARCH; RISK assessment; EVALUATION research; NEONATAL intensive care units; RANDOMIZED controlled trials; TREATMENT effectiveness; BLIND experiment
- Publication
Acta Paediatrica, 2019, Vol 108, Issue 1, p62
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.14497