We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The C-terminal region as a modulator of rNa<sub>v</sub>1.7 and rNa<sub>v</sub>1.8 expression levels
- Authors
Vijayaragavan, Kausalia; Acharfi, Said; Chahine, Mohamed
- Abstract
Mammalian cells poorly express rNav1.8 channels. In contrast, rNav1.7 dorsal root ganglion channels have 90-fold higher peak Na+ current densities. We investigated the role of rNav1.7 and rNav1.8 carboxy-termini in modulating the expression of rNav1.7 and rNav1.8 channels in tsA201 cells. Mutations in the ubiquitination site of the C-terminus did not improve rNav1.8 current levels. However, rNav1.8 chimeras containing the entire or the proximal portion of the rNav1.7 C-terminus expressed 3.2-fold and 4.8-fold higher peak current densities, respectively, than parent rNav1.8 channels. We conclude that the two Na+ channels may have different endoplasmic reticulum processing signals.
- Subjects
SODIUM channels; CELL physiology; TETRODOTOXIN; CELLULAR signal transduction
- Publication
FEBS Letters, 2004, Vol 559, Issue 1-3, p39
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(04)00019-5