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- Title
Ethanol cycle in an ethanologenic bacterium
- Authors
Kalnenieks, U.; Galinina, N.; Toma, M.M.; Marjutina, U.
- Abstract
A novel redox cycle is suggested, performing interconversion between acetaldehyde and ethanol in aerobically growing ethanologenic bacterium Zymomonas mobilis. It is formed by the two alcohol dehydrogenase (ADH) isoenzymes simultaneously catalyzing opposite reactions. ADH I is catalyzing acetaldehyde reduction. The local reactant ratio at its active site probably is shifted towards ethanol synthesis due to direct channeling of NADH from glycolysis. ADH II is oxidizing ethanol. The net result of the cycle operation is NADH shuttling from glycolysis to the membrane respiratory chain, and ensuring flexible distribution of reducing equivalents between the ADH reaction and respiration.
- Subjects
ALCOHOL dehydrogenase; ZYMOMONAS mobilis; CHEMOSTAT
- Publication
FEBS Letters, 2002, Vol 522, Issue 1-3, p6
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02923-X