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- Title
Prevalence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis and Prior Exposure to Hepatitis C.
- Authors
Vamauchi, Masayoshi; Nakahara, Masao; Maezawa, Yoshihiko; Satoh, Shyunnya; Nishikawa, Fuminori; Ohata, Mituru; Mizuhara, Yuji; Hirakawa, Junnichi; Nakajima, Hisato; Fujisawa, Kiyoshi; Toda, Gotaro
- Abstract
Sixty-three patients with alcoholic cirrhosis were retrospectively studied for the prevalence of antibodies to core (P22) and nonstructural (C100) region of hepatitis C virus (HCV). The prevalence rate of anti-F22 anti-bodies in patients with alcoholic cirrhosis was higher than that of anti-C100 antibodies (63.5% <em>vs.</em> 54.9%). The positivity rate of anti-C100 and/or anti-P22 anti-bodies was 73.0% (46/63) in alcoholic cirrhosis. We performed a multivariate analysis on the effects of age, sex, cumulative alcohol intake, anti-HCV antibodies, indocyanine green excretion test, and serum albumin on the development of hepatocellular carcinoma MCC in patients with cirrhosis, using Cox's proportional-hazards model, which revealed that anti-HCV positivity was the only independent prognostic variable for HCC in patients with alcoholic cirrhosis. The probability of HCC was significantly higher in the anti-HCV-positive patients than in the negative patients with alcoholic cirrhosis (<em>p</em> < 0.05). The 3-, 5- and 10-yr cumulative occurrence rate of HCC was, respectively, 13.3%, 41.3%, and 80.7% for anti HCV-positive patients with alcoholic cirrhosis, compared with 0%, 8.3%, and 18.5% for anti-HCV-negative patients. In nonalcoholic patients with type C cirrhosis, the 3-, 5-, and 10-yr cumulative occurrence rate of HCC was 7.3%, 23.1%, and 56.5%, respectively. The follow-up studies indicate that hepatocarcinogenesis is hastened significantly in patients with alcoholic cirrhosis if they are positive for anti-HCV antibody, and that heavy alcohol consumption also is a risk factor for the development of HCC in patients with type C cirrhosis.
- Subjects
LIVER cancer; CIRRHOSIS of the liver; COMPLICATIONS of alcoholism; HEPATITIS C virus; IMMUNOGLOBULINS
- Publication
American Journal of Gastroenterology (Springer Nature), 1993, Vol 88, Issue 1, p39
- ISSN
0002-9270
- Publication type
Article