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- Title
Urinary Pseudouridine as a Biochemical Marker in the Diagnosis and Monitoring of Primary Hepatocellular Carcinoma.
- Authors
Tamura, Shinsuke; Fujioka, Hiroshi; Nakano, Takashi; Amuro, Yoshiki; Hada, Toshikazu; Higashino, Kazuya; Nakao, Norio
- Abstract
The urinary level of pseudouridine, primarily a degradation product of transfer ribonucleic acid (tRNA), was determined in 38 patients with primary hepatocellular carcinoma, 18 with liver cirrhosis, 12 with chronic hepatitis, nine with acute hepatitis, and 28 healthy subjects. The mean urinary pseudouridine concentration was significantly higher in the patients with hepatoma [38.2 ± 12.8 (SD) nmol/µmol creatinine] than in those with liver cirrhosis (20.3 ± 6.8), chronic hepatitis (24.4 ± 8.2), and acute hepatitis (21.7 ± 8.2), and in healthy subjects (23.8 ± 4.9). Urinary pseudouridine level was elevated above the mean value plus 2 SD for the healthy subjects (33.6 nmol/µmol creatinine) in 71% of our hepatoma cases. Serum α-fetoprotein levels correlated poorly with urinary pseudouridine levels, thus, the combination assay for urinary pseudoaridine and serum α-fetoprotein could detect 79% of the patients with hepatoma. Moreover, urinary pseudouridine level was reduced after effective transcatheter arterial embolization therapy.
- Subjects
PSEUDOURIDINE; TRANSFER RNA; LIVER cancer; CANCER patients; HEPATITIS; HEPATOCELLULAR carcinoma
- Publication
American Journal of Gastroenterology (Springer Nature), 1988, Vol 83, Issue 8, p841
- ISSN
0002-9270
- Publication type
Article