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- Title
RAGE Against the ABCs.
- Authors
Allen, Terri J.; Murphy, Andrew J.; Jandeleit-Dahm, Karin A.
- Abstract
The article presents a commentary on the role of diabetes in the downregulation of the ATP binding cassette transporters ABCG1 and ABCA1 in macrophages. Topics discussed include the promotion of foam cell formation due to the downregulation of the transporters and the link between the RAGE signaling axis and the suppression of macrophage ABCA1/G1. Also mentioned is the role of carboxymethyllysine-advanced glycation end product in suppressing the transcription of ABCG1.
- Subjects
DOWNREGULATION; DIABETES; ATP-binding cassette transporters; MACROPHAGES; CARBOXYMETHYL compounds; LYSINE
- Publication
Diabetes, 2015, Vol 64, Issue 12, p3981
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/dbi15-0015