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- Title
The Incidence of Abnormal Glucose Metabolism in Hispanic Parents of Children with Acanthosis Nigricans.
- Authors
Menchaca, John; Willis, Benjamin; McConathy, Walter; Urrutia-Rojas, Ximena; Jimenez, Maria; Buttreddy, Sabitha; Marshall, Khiya; Bae, Sejong; Lacko, Andras; Spellman, Craig
- Abstract
Our objective was to assess the incidence of abnormal glucose metabolism in Hispanic parents whose children are positive for acanthosis nigricans (AN). Our hypothesis is that parents with such children are at higher risk for diabetes. METHODS: As part of an ongoing project (DREAMS, Diabetes Research Education and Metabolic Studies program) involving the primary prevention of Type 2 diabetes (T2D) and cardiovascular diseases, 258 Hispanic families with overweight children were evaluated for metabolic and anthropometric parameters including fasting blood glucose levels, AN status, and prior history of T2D diagnosis. The criteria used were fasting impaired glucose (IFG), abnormal glucose (>126 mg/dl), or prior diagnosis of T2D. RESULTS: Of 343 parents screened (229 mothers and 114 fathers), a total of 92 (30.0%) of the parents whose children were AN+ (acanthosis nigricans positive) were noted to have an abnormality of carbohydrate metabolism. In contrast, only 17 (18.3%) of the parents (p=0.048) with AN- (acanthosis nigricans negative) children had abnormal findings. Parents with AN+ children had 19.6% with IFG, 5.6% with abnormal glucose and 4.8% with diagnosis of T2D. On the other hand, parents of AN- children had 16.1% with IFG, 2.2% with abnormal glucose, and 0% with T2D. When mothers and fathers were considered separately, 17.3 % of the mothers with AN+ children had IFG levels compared to 7.1% with AN- children and 4.0% mothers with AN+ children had overtly elevated glucose compared to 1.8% with AN- children (p=0.028). Fathers of AN+ children showed a higher proportion of abnormal glucose levels compared to those with AN- children, but the difference was not significant. CONCLUSIONS: Our findings suggest Hispanic children with AN have parents with a higher incidence of carbohydrate metabolism abnormalities. It appears that mothers with AN+ children may be affected more frequently with abnormal glucose metabolism. Having a child with AN among Hispanics may need to be considered as an additional risk factor for focused screening of parents for T2D in this population.
- Subjects
BLOOD sugar; METABOLISM; HISPANIC American parents; ACANTHOSIS nigricans; DIABETES risk factors; TYPE 2 diabetes; PATIENTS
- Publication
Diabetes, 2007, Vol 56, pA524
- ISSN
0012-1797
- Publication type
Article