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- Title
Comparison of Central Aortic Pulse Wave Analysis Between Type 2 Diabetes Patients and Non-Diabetic Subjects.
- Authors
Jee In Lee; Tae Seo Sohn; Sung Dae Moon; Je Ho Han; Jung Min Lee; Sang Ah Chang; Seung Su Lee; Yu Sun Jib; Bong Yun Cha; Kyung Ah Han; Hyun Shik Son
- Abstract
As cardiovascular disease is the leading cause of mortality in patient with diabetes mellitus, increasing emphasis is being placed noninvasive techniques for early detection of subclinical cardiovascular disease. It is well that increased arterial stiffness was associated with cardiovascular morbidity and mortality. The aim of this study was to examine the change on central aortic pulse wave analysis between type 2 diabetes patients and non-diabetic subjects in Korea. Using the non-invasive technique of pulse wave analysis by applantation tonometry, we investigated aortic augmentation and central pressure in 45 patients with type 2 DM and 45 controls. Central aortic waveforms were generated, and augmentation pressure, augmentation index (AIx), ejection duration (ED) and subendocardial viability index (SEVR) were calculated. Patients with Type 2 diabetes had a significantly higher aortic AIx (137.51 ± 24.51% vs 128.67 ± 23.66%; P=0.01) and lower SEVR (160.35 ± 30.40 vs 167.51 ± 24.34; P=0.01) and lower ED (284.86 ±. 29.63 vs 301.96 ± 22.61; P=0.01) compared with controls. Higher AIx was associated with increased systemic arterial stiffness. Decreased SEVR and ED were associated with diastolic heart dysfunction. Augmentation index in patient with type 2 diabetes had a positive correlation with brachial diastolic pressure (r=0.524, p<0.001) and lipoprotein (a) (r=0.659, p <0.05) by multivariate regression analysis. These data showed that patients with type 2 diabetes had increased arterial stiffness and diastolic dysfunction. Diastolic blood pressure and lipoprotein (a) were independent determinants of aortic stiffness in patients with type 2 diabetes mellitus.
- Subjects
KOREA; CARDIOVASCULAR diseases; PEOPLE with diabetes; ARTERIAL diseases; TONOMETRY; BLOOD pressure; LIPOPROTEINS
- Publication
Diabetes, 2007, Vol 56, pA591
- ISSN
0012-1797
- Publication type
Article