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- Title
Changes of Retinol Binding Protein-4, Leptin, Adiponectin, and Interleukin-6 with Weight Loss through Lifestyle Modification in Type 2 Diabetes.
- Authors
Kyung Ah Han; Hyo-Jeong Kim; Hyun Jin Kim; Kang Seo Park; Kyung Wan Min; Eung Jin Kim
- Abstract
Adipose tissue is an active endocrine and paracrine organ that releases various cytokines that influence not only body weight homeostasis but insulin resistance. We investigated the changes and their relationship of adipokines including retinol binding protein 4(RBP-4), leptin, adiponectin, and interleukin 6 (IL-6) with weight loss in overweight or obese Type 2 diabetes. Sixty overweight or obese female subjects with type 2 diabetes were recruited for 4 week weight reduction program (age:55.3±8.5 years; body mass index(BMI): 27.8±5.6kg/m²). Twenty patients were randomly assigned to each three group;control, diet-dominant weight reduction group(DG), and exercise-dominant weight reduction group(EG). DG was recommended for low calorie diet (25 kcal per kg of ideal body weight) and EG was encouraged to walk about 2 hours, aiming at 300 kcal of exercise energy expenditure, individually prescribed by exercise physiologist. We measured fasting serum concentrations of RBP-4, leptin, adiponectin, and IL-6 and insulin-sensitivity index scores expressed as Kitt (percent decline in plasma glucose concentration per minute after bolus of regular human insulin) before and after 4 week trial. Seven subjects dropped out and data from 53 subjects were analyzed. Compared to baseline, BMI and leptin were decreased in DG and EG. RBP-4 didn't changed in control and DG, and increased in EG after 4 week trial. Adiponectin and IL-6 did not changed in all three groups (Table 1). In all subjects, percent change of leptin and RBP-4 were significantly correlated with percent change of BMI, but not related with Kitt. These findings suggested RBP-4 changed with BMI, possibly related with leptin in Type 2 diabetes.
- Subjects
VITAMIN A; CARRIER proteins; LEPTIN; PROTEIN hormones; INTERLEUKIN-6; WEIGHT loss; TYPE 2 diabetes; ADIPOSE tissues
- Publication
Diabetes, 2007, Vol 56, pA363
- ISSN
0012-1797
- Publication type
Article