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- Title
Baseline and Change in Visceral and Subcutaneous Adiposity Predict Future HDL Cholesterol, Triglycerides, and non HDL Cholesterol Levels in Japanese Americans.
- Authors
Hayashi, Tomoshige; Boyko, Edward J.; McNeely, Marguerite J.; Leonetti, Donna L.; Kahn, Steven E.; Fujimoto, Wilfred Y.
- Abstract
Central adiposity is generally considered to play a key role in the metabolic syndrome. The purpose of this study is whether abdominal fat depots directly measured by computed tomography (CT) and their changes during a follow-up period are associated with future levels of HDL cholesterol, triglycerides, and non-HDL cholesterol. In addition, we investigated whether these associations differed between men and women. We followed 376 Japanese Americans over 10-11 years who were not taking oral hypoglycemic medication or insulin at entry and not taking lipid lowering medications both at entry and at 10-11 year follow-up. Intra-abdominal fat area (IAFA) and abdomen subcutaneous fat area (ASFA) were measured at the umbilicus by CT. In men greater baseline IAFA was significantly associated with decreased future HDL cholesterol (standardized regression coefficient =-0.260 (p=0.007)) and increased future triglycerides (0.293 (p=0.003), but was not related to non-HDL cholesterol (0.088 (p=0.392)) in a regression model that included both baseline and change in IAFA, ASFA and its change, age, fasting plasma glucose, fasting plasma insulin, daily alcohol consumption, weekly energy expenditure, and smoking habit. Change over time in IAFA was significantly and positively correlated with higher future triglycerides (0.239 (p=0.002)) but not related to either future HDL cholesterol (-0.091 (p=0.222)) or non-HDL cholesterol (0.155 (p=0.057)). Neither ASFA nor its change were correlated with any future lipid level. In women both baseline and change in IAFA were correlated with decreased future HDL cholesterol (-0.610 (p<0.001), -0.396 (p<0.001) respectively), increased future triglycerides (0.315 (p=0.009), 0.434 (p<0.001) respectively), and non-HDL cholesterol (0.258 (p=0.045), 0.244 (p=0.007)) in a regression model that included the same variables as above. Greater ASFA at baseline was significantly correlated with higher future HDL cholesterol (0.248 (p=0.005) but was unrelated to triglycerides (-0.086 (p=0.379) or non-HDL cholesterol (-0.007 (p=0.948). In conclusion, greater IAFA and its change are independently associated with unfavorable future lipids levels. In women only, greater ASFA is independently associated with higher future HDL cholesterol.
- Subjects
FAT; ADIPOSE tissues; HIGH density lipoproteins; TRIGLYCERIDES; BLOOD cholesterol; HYPOGLYCEMIC agents; JAPANESE Americans
- Publication
Diabetes, 2007, Vol 56, pA263
- ISSN
0012-1797
- Publication type
Article