The article discusses the mechanisms of pain due to fibromyalgia (FM). It mentions that about 2% to 4% of the population in the U.S. tend to get affected by the condition in which they experience inflammatory pain. Features of FM are cited which include increased peripheral and central pain sensitivity or hyperalgesia and allodynia. It examines the role of peripheral tissues in clinical FM pain, noting that pain and hyperalgesia in such patients get amplified by painful muscles.