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- Title
MiRNA Differences Related to Treatment-Resistant Schizophrenia.
- Authors
Pérez-Rodríguez, Daniel; Penedo, Maria Aránzazu; Rivera-Baltanás, Tania; Peña-Centeno, Tonatiuh; Burkhardt, Susanne; Fischer, Andre; Prieto-González, José M.; Olivares, José Manuel; López-Fernández, Hugo; Agís-Balboa, Roberto Carlos
- Abstract
Schizophrenia (SZ) is a serious mental disorder that is typically treated with antipsychotic medication. Treatment-resistant schizophrenia (TRS) is the condition where symptoms remain after pharmacological intervention, resulting in long-lasting functional and social impairments. As the identification and treatment of a TRS patient requires previous failed treatments, early mechanisms of detection are needed in order to quicken the access to effective therapy, as well as improve treatment adherence. In this study, we aim to find a microRNA (miRNA) signature for TRS, as well as to shed some light on the molecular pathways potentially involved in this severe condition. To do this, we compared the blood miRNAs of schizophrenia patients that respond to medication and TRS patients, thus obtaining a 16-miRNA TRS profile. Then, we assessed the ability of this signature to separate responders and TRS patients using hierarchical clustering, observing that most of them are grouped correctly (~70% accuracy). We also conducted a network, pathway analysis, and bibliography search to spot molecular pathways potentially altered in TRS. We found that the response to stress seems to be a key factor in TRS and that proteins p53, SIRT1, MDM2, and TRIM28 could be the potential mediators of such responses. Finally, we suggest a molecular pathway potentially regulated by the miRNAs of the TRS profile.
- Subjects
MICRORNA; PATIENT compliance; SCHIZOPHRENIA; HIERARCHICAL clustering (Cluster analysis); DRUG therapy; ARIPIPRAZOLE
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 3, p1891
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24031891