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- Title
COVID-19 and One-Carbon Metabolism.
- Authors
Perła-Kaján, Joanna; Jakubowski, Hieronim
- Abstract
Dysregulation of one-carbon metabolism affects a wide range of biological processes and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer. Accumulating evidence suggests that one-carbon metabolism plays an important role in COVID-19. The symptoms of long COVID-19 are similar to those presented by subjects suffering from vitamin B12 deficiency (pernicious anemia). The metabolism of a cell infected by the SARS-CoV-2 virus is reshaped to fulfill the need for massive viral RNA synthesis, which requires de novo purine biosynthesis involving folate and one-carbon metabolism. Many aspects of host sulfur amino acid metabolism, particularly glutathione metabolism underlying antioxidant defenses, are also taken over by the SARS-CoV-2 virus. The purpose of this review is to summarize recent findings related to one-carbon metabolism and sulfur metabolites in COVID-19 and discuss how they inform strategies to combat the disease.
- Subjects
SULFUR amino acids; POST-acute COVID-19 syndrome; SULFUR metabolism; SARS-CoV-2; NEURAL tube defects
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 8, p4181
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23084181