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- Title
Design of Gelatin-Capped Plasmonic-Diatomite Nanoparticles with Enhanced Galunisertib Loading Capacity for Drug Delivery Applications.
- Authors
Tramontano, Chiara; Miranda, Bruno; Chianese, Giovanna; De Stefano, Luca; Forestiere, Carlo; Pirozzi, Marinella; Rea, Ilaria
- Abstract
Inorganic diatomite nanoparticles (DNPs) have gained increasing interest as drug delivery systems due to their porous structure, long half-life, thermal and chemical stability. Gold nanoparticles (AuNPs) provide DNPs with intriguing optical features that can be engineered and optimized for sensing and drug delivery applications. In this work, we combine DNPs with gelatin stabilized AuNPs for the development of an optical platform for Galunisertib delivery. To improve the DNP loading capacity, the hybrid platform is capped with gelatin shells of increasing thicknesses. Here, for the first time, full optical modeling of the hybrid system is proposed to monitor both the gelatin generation, degradation, and consequent Galunisertib release by simple spectroscopic measurements. Indeed, the shell thickness is optically estimated as a function of the polymer concentration by exploiting the localized surface plasmon resonance shifts of AuNPs. We simultaneously prove the enhancement of the drug loading capacity of DNPs and that the theoretical modeling represents an efficient predictive tool to design polymer-coated nanocarriers.
- Subjects
NANOCARRIERS; GOLD nanoparticles; SURFACE plasmon resonance; NANOPARTICLES; DRUG delivery systems
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 19, p10755
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms221910755