We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases.
- Authors
Anchang, Charles Gwellem; Xu, Cong; Raimondo, Maria Gabriella; Atreya, Raja; Maier, Andreas; Schett, Georg; Zaburdaev, Vasily; Rauber, Simon; Ramming, Andreas
- Abstract
Immune-mediated inflammatory diseases (IMIDs), such as inflammatory bowel diseases and inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis), are marked by increasing worldwide incidence rates. Apart from irreversible damage of the affected tissue, the systemic nature of these diseases heightens the incidence of cardiovascular insults and colitis-associated neoplasia. Only 40–60% of patients respond to currently used standard-of-care immunotherapies. In addition to this limited long-term effectiveness, all current therapies have to be given on a lifelong basis as they are unable to specifically reprogram the inflammatory process and thus achieve a true cure of the disease. On the other hand, the development of various OMICs technologies is considered as "the great hope" for improving the treatment of IMIDs. This review sheds light on the progressive development and the numerous approaches from basic science that gradually lead to the transfer from "bench to bedside" and the implementation into general patient care procedures.
- Subjects
PSORIATIC arthritis; INFLAMMATION; RHEUMATOID arthritis; DISEASE incidence; ARTHRITIS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 14, p7506
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22147506