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- Title
GMI, an Immunomodulatory Peptide from Ganoderma microsporum , Restrains Periprosthetic Joint Infections via Modulating the Functions of Myeloid-Derived Suppressor Cells and Effector T Cells.
- Authors
Peng, Kuo-Ti; Chen, Jiun-Liang; Kuo, Liang-Tseng; Yu, Pei-An; Hsu, Wei-Hsiu; Lee, Chiang-Wen; Chang, Pey-Jium; Huang, Tsung-Yu
- Abstract
Periprosthetic joint infections (PJIs) caused by Staphylococcus aureus infection are difficult to treat due to antibiotic resistance. It is known that the biofilms from methicillin-resistant S. aureus (MRSA) promote expansion of myeloid-derived suppressor cells (MDSCs) to suppress T-cell proliferation and benefit bacterial infections. This study finds that GMI, a fungal immunomodulatory peptide isolated from Ganoderma microsporum, suppresses MDSC expansion to promote the proliferation of cytotoxic T cells. The enhancement is likely attributed to increased expression of IL-6 and TNF-α and reduction in ROS expression. Similar beneficial effects of GMI on the suppression of MDSC expansion and IL-6 expression are also observed in the whole blood and reduces the accumulation of MDSCs in the infected bone region in a mouse PJI infection model. This study shows that GMI is potentially useful for treating S. aureus-induced PJIs.
- Subjects
REGULATORY T cells; MYELOID-derived suppressor cells; JOINT infections; CYTOTOXIC T cells; STAPHYLOCOCCUS aureus infections; T cells
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 13, p6854
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22136854