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- Title
The Hidden Role of Hydrogen Sulfide Metabolism in Cancer.
- Authors
Wang, Rong-Hsuan; Chu, Yu-Hsin; Lin, Kai-Ti
- Abstract
Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, and pro-angiogenesis. In cancer, aberrant up-regulation of H2S-producing enzymes is frequently observed in different cancer types. The recognition that tumor-derived H2S plays various roles during cancer development reveals opportunities to target H2S-mediated signaling pathways in cancer therapy. In this review, we will focus on the mechanism of H2S-mediated protein persulfidation and the detailed information about the dysregulation of H2S-producing enzymes and metabolism in different cancer types. We will also provide an update on mechanisms of H2S-mediated cancer progression and summarize current options to modulate H2S production for cancer therapy.
- Subjects
HYDROGEN sulfide; CANCER invasiveness; ENZYME metabolism; METABOLISM; CANCER treatment; VASODILATION; NEOVASCULARIZATION
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 12, p6562
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22126562