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- Title
The Endocannabinoid System: A Target for Cancer Treatment.
- Authors
Laezza, Chiara; Pagano, Cristina; Navarra, Giovanna; Pastorino, Olga; Proto, Maria Chiara; Fiore, Donatella; Piscopo, Chiara; Gazzerro, Patrizia; Bifulco, Maurizio
- Abstract
In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
- Subjects
CANCER treatment; CANCER pain; TREATMENT effectiveness; CANNABINOIDS; CANCER invasiveness; CELL growth; CANNABINOID receptors
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 3, p747
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21030747