We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lynch Syndrome-Related Clear Cell Carcinoma of the Cervix: A Case Report.
- Authors
Kohei Nakamura; Kentaro Nakayama; Toshiko Minamoto; Tomoka Ishibashi; Kaori Ohnishi; Hitomi Yamashita; Ruriko Ono; Hiroki Sasamori; Razia, Sultana; Hossain, Mohammad Mahmud; Kamrunnahar, Shanta; Masako Ishikawa; Noriyoshi Ishikawa; Satoru Kyo
- Abstract
Lynch syndrome, a hereditary cancer syndrome, occurs because of germline mutations in at least one of four DNA mismatch repair genes (MutL Homolog 1 (MLH1), MutS Homolog 2 (MSH2), MutS Homolog 6 (MSH6), and PMS1 Homolog 2 (PMS2)). The disorder is associated with colorectal, endometrial, and other epithelial malignancies, but not cervical cancer. We report a woman with Lynch syndrome with synchronous cervical cancer. This is the first report of Lynch syndrome-related clear cell carcinoma of the cervix, which indicates the possibility of an association between cervical cancer and Lynch syndrome. Suitable genetic tests are required to determine whether common genetics can account for synchronous or subsequent malignancies in Lynch syndrome patients and their families. Such knowledge will also enhance our understanding of the genetic mechanisms governing the development of apparently unrelated cancers.
- Subjects
HEREDITARY nonpolyposis colorectal cancer; EPITHELIAL cell tumors; CANCER genetics; METASTASIS
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 4, p979
- ISSN
1661-6596
- Publication type
Case Study
- DOI
10.3390/ijms19040979