We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
RNase 7 in Cutaneous Defense.
- Authors
Rademacher, Franziska; Simanski, Maren; Harder, Jürgen
- Abstract
RNase 7 belongs to the RNase A superfamily and exhibits a broad spectrum of antimicrobial activity against various microorganisms. RNase 7 is expressed in human skin, and expression in keratinocytes can be induced by cytokines and microbes. These properties suggest that RNase 7 participates in innate cutaneous defense. In this review, we provide an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases.
- Subjects
RIBONUCLEASES; ANTI-infective agents; DISULFIDES; KERATINOCYTES; ANIMAL chemical defenses; GENE expression
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 4, p560
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17040560