We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs.
- Authors
Ching-Ju Shen; Chi-Chang Chang; Yi-Tz Chen; Chung-Sheng Lai; Yi-Chiang Hsu
- Abstract
Melatonin is found in animals as well as plants. In animals, it is a hormone that anticipates the daily onset of darkness and regulates physiological functions, such as sleep timing, blood pressure, and reproduction. Melatonin has also been found to have anti-tumor properties. Malignant cancers are the most common cause of death, and the mortality rate of ovarian tumor is the highest among gynecological diseases. This study investigated the anti-tumor effects of melatonin on the ovarian cancer lines, OVCAR-429 and PA-1. We observed the accumulation of melatonin-treated cells in the G1 phase due to the down-regulation of CDK 2 and 4. Our results suggest that in addition to the known effects on prevention, melatonin may also provide anti-tumor activity in established ovarian cancer.
- Subjects
MELATONIN; CANCER genetics; OVARIAN cancer; CANCER cells; CELLULAR immunity; CYCLIN-dependent kinases; CELL lines
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 2, p176
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17020176