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- Title
Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities.
- Authors
Pereira Beserra, Fernando; de Cássia Santos, Raquel; Lucena Périco, Larissa; Peixoto Rodrigues, Vinicius; de Almeida Kiguti, Luiz Ricardo; Saldanha, Luiz Leonardo; Sampaio Pupo, André; Machado da Rocha, Lúcia Regina; Dokkedal, Anne Lígia; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko
- Abstract
The objective of this study was to evaluate the pharmacological mechanisms involved in anti-inflammatory and antidiarrheal actions of hydroalcoholic extract obtained from the leaves of Cissus sicyoides (HECS). The anti-inflammatory effect was evaluated by oral administration of HECS against acute model of edema induced by xylene, and the mechanisms of action were analysed by involvement of arachidonic acid (AA) and prostaglandin E2 (PGE2). The antidiarrheal effect of HECS was observed and we analyzed the motility and accumulation of intestinal fluid. We also analyzed the antidiarrheal mechanisms of action of HECS by evaluating the role of the opioid receptor, α2 adrenergic receptor, muscarinic receptor, nitric oxide (NO) and PGE2. The oral administration of HECS inhibited the edema induced by xylene and AA and was also able to significantly decrease the levels of PGE2. The extract also exhibited significant anti-diarrheal activity by reducing motility and intestinal fluid accumulation. This extract significantly reduced intestinal transit stimulated by muscarinic agonist and intestinal secretion induced by PGE2. Our data demonstrate that the mechanism of action involved in the anti-inflammatory effect of HECS is related to PGE2. The antidiarrheal effect of this extract may be mediated by inhibition of contraction by acting on the intestinal smooth muscle and/or intestinal transit.
- Subjects
CISSUS; ANTI-inflammatory agents; ANTIDIARRHEALS; ARACHIDONIC acid; SMOOTH muscle proteins
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 2, p149
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17020149