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- Title
Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats.
- Authors
Li Zhang; Zhijie He; Qi Zhang; Yi Wu; Xiaojiao Yang; Wenxiu Niu; Yongshan Hu; Jie Jia
- Abstract
Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions.
- Subjects
NEUROPROTECTIVE agents; MITOCHONDRIAL DNA; CEREBRAL ischemia; LABORATORY rats; MAGNETIC resonance imaging; TREADMILL exercise
- Publication
International Journal of Molecular Sciences, 2014, Vol 15, Issue 3, p4453
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms15034453