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- Title
Sparing Effects of Sufentanil on Epidural Ropivacaine in Elderly Patients Undergoing Transurethral Resection of Prostate Surgery.
- Authors
Huiling Li; Yuhong Li; Rui He
- Abstract
Purpose: This study examined the sparing effect of sufentanil on the median effective concentration (EC50) of epidural ropivacaine in elderly patients undergoing elective transurethral resection of prostate (TURP). Materials and Methods: This was a prospective randomized double-blind dose-response study. Fifty eight elderly patients with American Society of Anesthesiologists physical status I-II who were scheduled for TURP surgery under epidural anesthesia were randomly allocated to a group receiving 15 mL of ropivacaine (group R) or a group receiving ropivacaine plus 5 µg of sufentanil (group RS). The concentration of ropivacaine was determined by a Dixon's up-and-down sequential allocation. The first participant received 0.3% of ropivacaine in both groups and subsequent concentrations were determined by the response of the previous patient in the same group. The EC50 of epidural ropivacaine was analyzed using the Dixon and Massey method. Results: The EC50 of ropivacaine during TURP surgery was 0.186% (95% confidence interval, 0.173-0.200%) in group R, and 0.136% (95% confidence interval, 0.127-0.144%) in group RS (p<0.01). No differences in Bromage scale of motor block examination and the onset time of sensory block were observed. Conclusion: Administration of 5 μg of epidural sufentanil caused a 37% reduction in the EC50 of epidural ropivacaine in elderly patients who underwent TURP surgery. Thus, sufentanil addition during surgery of TURP can decrease the dose of ropivacaine anesthesia required.
- Subjects
PROSTATE surgery; SUFENTANIL; EPIDURAL injections; TRANSURETHRAL prostatectomy; OLDER patients; DRUG efficacy; AMERICAN Society of Anesthesiologists
- Publication
Yonsei Medical Journal, 2015, Vol 56, Issue 3, p832
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2015.56.3.832