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- Title
Vaccinomics and Personalized Vaccinology: Is Science Leading Us Toward a New Path of Directed Vaccine Development and Discovery?
- Authors
Poland, Gregory A.; Kennedy, Richard B.; Ovsyannikova, Inna G.
- Abstract
As is apparent in many fields of science and medicine, the new biology, and particularly new high-throughput genetic sequencing and transcriptomic and epigenetic technologies, are radically altering our understanding and views of science. In this article, we make the case that while mostly ignored thus far in the vaccine field, these changes will revolutionize vaccinology from development to manufacture to administration. Such advances will address a cur- rent major barrier in vaccinology--that of empiric vaccine discovery and development, and the subsequent low yield of viable vaccine candidates, particularly for hyper- variable viruses. While our laboratory's data and thinking (and hence also for this paper) has been directed toward viruses and viral vaccines, generalization to other pathogens and disease entities (i.e., anti-cancer vaccines) may be appropriate.
- Subjects
VACCINES; DRUG development; GENETIC transcription; EPIGENETICS; VIRUSES
- Publication
PLoS Pathogens, 2011, Vol 7, Issue 12, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1002344