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- Title
An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms.
- Authors
Bartlett, Alice I.; Radford, Sheena E.
- Abstract
In recent years, improvements in experimental techniques and enhancements in computing power have revolutionized our understanding of the mechanisms of protein folding. By combining insights gained from theory, experiment and simulation we are moving toward an atomistic view of folding landscapes. Future challenges involve exploiting the knowledge gained and methods developed to enable us to elucidate a molecular description of folding dynamics in the complex environment of the cell.
- Subjects
PROTEIN folding; POLYPEPTIDES; PROTEIN structure; CYTOLOGICAL research; EXPERIMENTAL design; SIMULATION methods &; models
- Publication
Nature Structural & Molecular Biology, 2009, Vol 16, Issue 6, p582
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.1592