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- Title
Diastereoselective Synthesis of Substituted Tetrahydroisoquinolines and Isoindolines via a Silver(I) Triflate-Promoted Tandem Reaction.
- Authors
Xing, Siyang; Ren, Jing; Wang, Kui; Cui, Hong; Yan, Han; Li, Wenrui
- Abstract
A new silver(I) triflate-promoted tandem reaction comprising the ring opening of aziridines and a Michael reaction has been developed. Using secondary amines or primary amines as nucleophiles, this methodology allows for the synthesis of cis-1-alkyl-4-aminotetrahydroisoquinolines or cis-1,3-disubstituted isoindolines in good yields with excellent diastereoselectivities, respectively. Besides, easy operation and mild reaction conditions are also notable features of this tandem reaction.
- Subjects
TETRAHYDROISOQUINOLINES; INDOLINE; HETEROCYCLIC compounds synthesis; SILVER compounds; MICHAEL reaction; CHEMICAL yield
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 4, p532
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500903